Nature, Published online: 19 August 2026; doi:10. 1038/s41586-026-10933-6 A one-pot skeletal-editing reaction replaces isoxazole oxygen with carbon to form challenging pyrroles, enabled by an N-propargylic enaminone intermediate and a computational model predicting reaction outcomes.
Source: [Nature](https://www.nature.com/articles/s41586-026-10933-6)