In 1562, Cardinal Giovanni de Medici, a scion of the dynastic family that dominated politics and banking in Tuscany during the Renaissance, died of malaria. Twenty-five years later, his older brother, Grand Duke Francesco de Medici, succumbed to the same disease.
Source: [Phys.org](https://phys.org/news/2026-06-medici-brothers-reveal-renaissance-era.html)