Nature, Published online: 24 June 2026; doi:10. 1038/s41586-026-10697-z Chronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing cholesterol clearance, whereas CTSA inhibition restores LDLR func...

Source: [Nature](https://www.nature.com/articles/s41586-026-10697-z)

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